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Diclazepam (Ro5-3448), also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.

Names:	Diclazepam chlorodiazepam, 7-Chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Ro5-3448
IUPAC name:	7-chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
Substance group:	Benzodiazepines
Effect group:	Sedatives/hypnotics
Structure:
CAS Number:	2894-68-0
InChI:	InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3
InChI Key:	VPAYQWRBBOGGPY-UHFFFAOYSA-N
SMILES:	O=C1N(C)C2=CC=C(Cl)C=C2C(C3=CC=CC=C3Cl)=NC1
Molecular Formula:	C16H12Cl2N2O
Molecular Weight:	319.1853 g/mol
Control status:	71/IV
Year of scheduling:	2021
Description:	This substance is included in Schedule IV of the 1971 Convention on Psychotropic Substances.

In animal models, its effects are similar to diazepam, possessing long-acting anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.^{[citation needed]}

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What is Diclazepam?  

Diclazepam is also known as Chlorodiazepam. This research chemical falls under the benzodiazepine class. Diclazepam was first synthesized in the 1960s. Many researchers experiment with this chemical in order to witness results that are typical of other benzodiazepines.  Experiments with Diclazepam typically yield findings of muscle relaxation, sedation, disinhibition, anxiety suppression, thought deceleration, analysis suppression, dream potentiation, and residual sleepiness. Researchers should be well aware of the residual sleepiness findings before they begin experimenting with Diclazepam in their laboratories.   

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Diclazepam (also known as Chlorodiazepam) is a synthetic depressant substance of the benzodiazepine chemical class that produces effects similar to diazepam, such as anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia when administered.

Diclazepam, also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960.

Diclazepam (chlorodiazepam) is the short name for 7-chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one and can be considered both to be the 2′-chloro analogue of diazepam or the 1-methyl analogue of Delorazepam. This chemical is a novel research chemical and is not currently subject to any licensing controls or regulations in the UK when used for laboratory research and development purposes.

It is an analogue of the sedative diazepam (Valium), Diclazepam is a benzodiazepine drug with, among others, hypnotic, sedative, and anxiolytic properties. Part of the tranquiliser class.

Diclazepam is also available in pellet form, and can be used as a substitute for etizolam in comparable study conditions.

As with all the chemicals that we stock, Diclazepam is not approved for any type of in-vivo research (i.e. not in humans or animals) or for clinical trials and therefore if accidently ingested then immediate medical attention should be sought. Please ensure you adhere to standard laboratory safety practices including using suitable skin, eye and clothing protection.

Diclazepam, also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960.

Diclazepam (chlorodiazepam) is the short name for 7-chloro-5-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one and can be considered both to be the 2′-chloro analogue of diazepam or the 1-methyl analogue of Delorazepam. This chemical is a novel research chemical and is not currently subject to any licensing controls or regulations in the UK when used for laboratory research and development purposes.

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Diclazepam also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine designer drug and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as a recreational drug and research chemical. Efficacy and safety have not been tested in humans.

In animal models, its effects are similar to diazepam, possessing long-acting anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

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Always make sure you take adequate safety precautions. For example, remember to cover exposed skin and wear safety glasses. Diclazepam is intended for laboratory use only

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Diclazepam (Ro5-3448), also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.

It is an analogue of the sedative diazepam (Valium), it is a benzodiazepine drug with, among others, hypnotic, sedative, and analytical properties. Part of the tranquilizer class.

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Metabolism

Metabolism of this compound has been assessed,^[2] revealing diclazepam has an approximate elimination half-life of 42 hours and undergoes N-demethylation to delorazepam, which can be detected in urine for 6 days following administration of the parent compound.^[8] Other metabolites detected were lorazepam and lormetazepam which were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by cytochrome P450 enzymes occurring concurrently with N-demethylation.

Legal status

United Kingdom

In the UK, diclazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other benzodiazepine drugs.^[9]

United States

On December 23, 2022, the DEA announced it had begun consideration on the matter of placing Diclazepam under temporary Schedule I status.^[10]

Later on July 25, 2023, the DEA published a pre-print notice that Diclazepam would become temporarily scheduled as a Schedule I controlled substance from 07/26/2023 to 07/26/2025

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Diclazepam also known as chlorodiazepam and 2′-chloro-diazepam, is a benzodiazepine and functional analog of diazepam. In animal models, its effects are similar to diazepam, possessing long-acting anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

Quick Details

Product Name: Diclazepam
Synonyms: Diclazepam, 2-Chlorodiazepam, o-Chlorodiazepam
CAS No.: 2894-68-0
Molecular Formula: C16H12Cl2N2O
IUPAC: 7-chloro-5-(2-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Molecular weight: 319.2 g/mol
Purity: 99.6%
Appearance: White crystalline powder / off-white powder

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