Cheap Bromazolam Powder For sale. Bromazolam is a designer benzodiazepine that has recently emerged on the drug market. It is structurally related to traditional benzodiazepines and is known for its sedative, hypnotic, anxiolytic, and anticonvulsant activities. Bromazolam has been detected in post-mortem cases, indicating its use and potential abuse in some populations[“].

Synthesis Analysis

While the provided papers do not directly describe the synthesis of bromazolam, they do provide insights into the synthesis of related compounds. For example, the synthesis of 4-bromo-2,5-substituted oxazoles from N-arylethylamides using solar photo-thermochemical reactions is detailed, which involves bromination and intramolecular nucleophilic substitution steps[“]. This information could be relevant to the synthesis of bromazolam, as similar bromination reactions may be involved.

Molecular Structure Analysis

Bromazolam is likely to share structural similarities with other triazolo-benzodiazepines, such as brotizolam, which is a triazolo-1,4-thienodiazepine derivative[“]. The molecular structure of bromazolam would include a triazole ring fused to a benzodiazepine core, which is characteristic of this class of compounds.

Chemical Reactions Analysis

The enzymatic synthesis of bromo- and chlorocarbazoles provides an example of how bromination reactions can occur in the environment, potentially forming brominated analogs of various compounds[“]. Although this does not directly relate to bromazolam, it demonstrates the types of chemical reactions that brominated compounds can undergo.

Physical and Chemical Properties Analysis

The physical and chemical properties of bromazolam are not explicitly detailed in the provided papers. However, based on its classification as a benzodiazepine, it can be inferred that bromazolam would have properties conducive to crossing the blood-brain barrier, such as lipophilicity. The pharmacokinetic study of brotizolam, a related compound, indicates rapid absorption and a short elimination half-life, which could be similar for bromazolam[“].

Case Studies and Concentrations

Bromazolam has been detected in post-mortem cases, with concentrations ranging from 0.5 to 319.3 ng/mL. These cases often involved co-occurring substances such as fentanyl, suggesting that bromazolam may be used to enhance the effects of opioids[“]. Another study provided plasma concentrations of bromazolam in the low µg/L range, emphasizing the need for sensitive analytical methods to detect such compounds[“].

Scientific research applications

Analytical Toxicology and Metabolism

Bromazolam, a designer benzodiazepine, was first detected in British Columbia in 2021. Analysis of post-mortem cases using liquid-chromatography high resolution mass spectrometry showed that bromazolam was detected in 41 cases, often in conjunction with opioids like fentanyl. This study highlights its significance in forensic toxicology and the importance of sensitive detection methods for novel psychoactive substances (Mérette et al., 2023).
Another study focused on the metabolic profile of bromazolam, identifying eight metabolites in vitro and in vivo. This research is critical for understanding its metabolism and designing effective screening procedures in toxicology, emphasizing the roles of cytochrome P450 and UDP-glucuronosyltransferase isozymes in its metabolic transformations (Wagmann et al., 2020).

Pharmacological Research

Studies on brotizolam, a triazolo-1,4-thienodiazepine similar to bromazolam, have shown its impact on sleep and performance in healthy adults. This research contributes to understanding the pharmacological effects of related compounds on sleep variables and cognitive functions (Nicholson, Stone, & Pascoe, 1980).
Research on the inhibition of myocardial K+ channels by bromobenzoyl-methyladamantylamine, a related compound, suggests potential applications in cardiac pharmacology. Such studies provide insights into the mechanisms of action of bromazolam-related substances on cardiac function (Mészáros et al., 1982).

Veterinary Applications

Brotizolam has been studied for its effects on reducing fear in calves exposed to a novel object test, demonstrating its potential use in veterinary medicine for managing anxiety in animals (Reenen et al., 2009).

Clinical Trials in Insomnia and Anxiety

Several clinical trials have investigated the efficacy of brotizolam in treating insomnia and anxiety. These studies provide a basis for understanding the therapeutic potential of similar compounds like bromazolam in managing sleep disorders and anxiety (Langley & Clissold, 2020; Roehrs et al., 1983; Mamelak, Csima, & Price, 1983).

Neuropharmacology

Research on the effects of brotizolam on the central nervous system in animals highlights its potential for understanding the neuropharmacological properties of similar compounds like bromazolam. Such studies provide insights into their sedative, anxiolytic, and anticonvulsant effects (Kimishima et al., 1984).

properties

CAS RN	71368-80-4	Source

Retrosynthesis Analysis

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CAS 71368-80-4 Bromazolam | Products & Prices & Suppliers

Bromazolam is a chemical compound with the molecular formula C17H13BrN4. It belongs to the class of benzodiazepine drugs, which are known for their central nervous system depressant effects. Structurally, bromazolam is a derivative of benzodiazepine, a class of psychoactive substances that exert their pharmacological effects by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. In terms of physical properties, bromazolam typically presents as a white or off-white crystalline powder.As a benzodiazepine, bromazolam is commonly associated with anxiolytic (anxiety-reducing), sedative, and hypnotic properties. Benzodiazepines like bromazolam act by binding to the GABA-A receptor and modulating its function, leading to an inhibitory effect on the central nervous system.Bromazolam is not approved for medical use in many countries and is often encountered in the context of research chemicals or designer drugs. Due to its potent sedative effects, it poses a risk of misuse, dependence, and adverse reactions, and its sale may be restricted or prohibited in certain jurisdictions.

Name: Bromazolam
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