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What is Bromazolam?
Bromazolam was first synthesized back in 1976, but was never commercially marketed and not identified until much later in the early 2000s by the EMCDDA in Sweden.
Also known as 8-bromo-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine or XLI-268, Buy Bromazolam online always available.
It shares most of its structural properties with Alprazolam (brand name Xanax) and this is reflected in the anxiolytic and sedative effects that are reported in laboratory studies.
A fairly substantial amount of information about Bromazolam and its effects is reported in studies found on internet forums, however, regarding future legality and possible inclusion in the Opium Act remains unclear. We are always on point.
For now, it remains legal in much of Europe, so at Chemical Planet we are happy to offer laboratory-grade Bromazolam Powder and 3mg Bromazolam Pellets for your research purposes.
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Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) which was first synthesised in 1976, however was never ever marketed. It has subsequently been sold as a designer drug, initially being definitively determined by the EMCDDA in Sweden in 2016. It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic impacts to it and other benzodiazepines.
Bromazolam is a non subtype selective agonist at the benzodiazepine website of GABAA receptors, with a binding affinity of 2.81 nM at the α1 subtype, 0.69 nM at α2 and 0.62 nM at α5.
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Short-term treatment of insomnia.
Stress and anxiety conditions such as OCD and general stress and anxiety disorder, mostly as a short-term medication to be used simply on an at-need basis.
Negative effects:
Long term use may result in blepharospasms, specifically in women. Dosages of 4 mg or more might trigger anterograde amnesia.
In unusual cases, erythema annulare centrifugum skin sores have resulted.
Tolerance, dependence and withdrawal
Abrupt or quick discontinuation from Bromazolam , similar to benzodiazepines, may result in the look of the benzodiazepine withdrawal syndrome, consisting of rebound insomnia.
This is particularly appropriate provided Bromazolam short half life relative to benzodiazepines such as diazepam resulting in a more fast drug level decrease in blood plasma levels.
In a study that compared the efficiency of etizolam, alprazolam, and bromazepam for the treatment of generalized anxiety disorder, all 3 drugs kept their effectiveness over 2 weeks, but Bromazolam became more effective from 2 weeks to 4 weeks. Administering 0.5 grams Bromazolam two times daily did not induce cognitive deficits over 3 weeks when compared to placebo.
When several dosages of Bromazolam , or lorazepam, were administered to rat nerve cells, lorazepam caused downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam triggered a boost in alpha-2 benzodiazepine binding websites (reverse tolerance to anti-anxiety impacts).
Tolerance to the anticonvulsant results of lorazepam was observed, but no significant tolerance to the anticonvulsant results of etizolam was observed. Bromazolam therefore has actually a lowered liability to cause tolerance, and dependence, compared with classic benzodiazepines.
Bromazolam might represent a possible anxiolytic of choice with reduced liability to produce tolerance and reliance after long-term treatment of anxiety and tension syndromes.
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Cases of intentional suicide by overdose utilizing Bromazolam in mix with GABA agonists have been reported. Although Bromazolam has a lower LD50 than specific benzodiazepines, the LD50 is still far beyond the prescribed or recommended dose.
Flumazenil, a GABA antagonist agent used to reverse benzodiazepine overdoses, prevents the impact of Bromazolam in addition to classical benzodiazepines such as diazepam and chlordiazepoxide.
Bromazolam overdose deaths are increasing – for instance, the National Records of Scotland report on drug-related deaths, ‘street’ Bromazolam was a consider (“linked in, or possibly contributed to”) 752, or 59%, of drug-related deaths in Scotland in 2019.
It is essential to highlight that more than one drug added to the huge majority of the deaths (by way of contrast, opiates and opioids were a factor in 1092, or 86%, of drug-related deaths).
Safety Measures
Due to its potency and associated side effects, it’s recommended that gloves, eyewear, and respirators are used when handling Bromazolam Powder in the lab.
Bromazolam Pellets, however, are considerably more stable but great caution should always be taken with this novel compound.
In the event of accidental exposure, it is recommended to show the product label (containing the IUPAC information) to medical professionals. Accidental contact with the eyes should be treated swiftly by thorough rinsing with water after the removal of contact lenses.
Bromazolam is a powerful benzodiazepine derivative, but it is not the same as Valium. Unfortunately, too many people have seen Valium and then had bad experiences with it. Bromazolam is not nearly as bad as Valium. Many people that have tried both substances have given their opinions on the two. While I hold no bias for Valium and my opinion is irrelevant, I personally feel that Bromazolam is a much better alternative to Valium.
Bromazolam is a sleep aid that is extremely popular as a sleeping pill. This drug is not only commonly known as the “go-to” for sleeping pills, but it is also a popular alternative to Oxycodone for some users. In many degenerative disorders, such as Alzheimer’s, the effects of Bromazolam are more pronounced than other drugs that are known to be pharmaceuticals. There are some people who use Bromazolam because they feel that it relaxes them, while others use it as a substitute for other sleeping drugs.
How to Store Bromazolam?
Like any compound, there are things to avoid when storing Bromazolam Powder or Bromazolam Pellets such as; Direct sunlight, excessive humidity, and moisture.
Ensuring the ambient room temperature is not excessive will also help preserve your Bromazolam Powder and Bromazolam Pellets. If stored well in a cool, dry, and dark environment, Bromazolam can remain active for up to 2 years. For more about Bromazolam Contact US
| Names: | Bromazolam 8-bromo-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine |
|---|---|
| IUPAC name: | 8-bromo-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine |
| Substance group: | Benzodiazepines |
| Effect group: | Sedatives/hypnotics |
| Structure: | |
| CAS Number: | 71368-80-4 |
| InChI: | InChI=1S/C17H13BrN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3 |
| InChI Key: | KCEIOBKDDQAYCM-UHFFFAOYSA-N |
| SMILES: | CC1=NN=C2N1C3=CC=C(Br)C=C3C(C4=CC=CC=C4)=NC2 |
| Molecular Formula: | C17H13BrN4 |
| Molecular Weight: | 353.2159 g/mol |
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