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Buy Bromazolam Cas 71368-80-4. Bromazolam powder for sale. Bromazolam for sale is a chemical of the Benzodiazepine class. This product was first synthesized in 1976 but hadn’t been available to the Research Chemical for sale market until 2016. buy Bromazolam powder can often be compared to Alprazolam for sale as they are both chemically similar. Naturally a potent chemical, we do not advise that participants with little Diazepine experience to research this product in higher doses. Anecdotal reports have stated that participants had exhibited results of stress relief, euphoria and relaxation. Buy Bromazolam Cas 71368-80-4
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| Kinase experiment [1]: | |
| Preparation Method | They were treated with pHLS9 (2 mg protein /mL), 25 μg/mL Alamethicin (UGT reaction mixture B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, and 0.6 mM at 37°C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase and 0.1 mM acetyl-CoA. Then, 2.5 mM UDP-glucuronic acid (UGT reaction mixture solution A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, and 50 μM clobromazolam or Bromazolam were added. Buy Bromazolam Cas 71368-80-4 |
| Reaction Conditions | 50 μM Bromazolam for 360min in 37°C |
| Applications | Bromazolam metabolites were identified in pHLS9 incubation. |
| References: Buy Bromazolam Cas 71368-80-4[1]: Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR. Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam. J Anal Toxicol. 2021 Nov 9;45(9):1014-1027. doi: 10.1093/jat/bkaa161. PMID: 33048135. | |
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Bromazolam is a triazolobenzodiazepine that is known as research chemical XLI-268. Bromazolam is structurally similar to alprazolam but is the bromo rather than the chloro analog. Bromazolam metabolites were identified in pHLS9 incubation.Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD),It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines.Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81nM at the α1 subtype, 0.69nM at α2 and 0.62nM at α5. Buy Bromazolam Cas 71368-80-4
References:
[1]: PubChem. 8-Bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine. pubchem.ncbi.nlm.nih.gov website. Accessed August 18, 2021. https://pubchem.ncbi.nlm.nih.gov/compound/12562546
[2]: McDermott S, Johnson BE, Balasanova AA. Phenibut and Bromazolam Use Disorders Requiring Hospitalization for Medically Supervised Withdrawal. Prim Care Companion CNS Disord. 2022 Jul 12;24(4):21cr03119. doi: 10.4088/PCC.21cr03119. PMID: 35830740.
[3]: Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR. Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam. J Anal Toxicol. 2021 Nov 9;45(9):1014-1027. doi: 10.1093/jat/bkaa161. PMID: 33048135. Buy Bromazolam Cas 71368-80-4
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| Cas No. | 71368-80-4 | SDF | |
| Chemical Name | 8-bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | ||
| Canonical SMILES | CC1=NN=C(N1C2=CC=C(Br)C=C23)CN=C3C4=CC=CC=C4 | ||
| Formula | C17H13BrN4 | M.Wt | 353.2 |
| Solubility | 20mg/mL in DMSO, 30mg/mL in DMSO, 10mg/mL in Ethanol | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request | ||
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Bromazolam powder for sale was first synthesized back in 1976, but was never commercially marketed and not identified until much later in the early 2000’s by the EMCDDA in Sweden.
Also known as 8-bromo-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine or XLI-268,
It shares the most of its structural properties with Alprazolam (brand name Xanax) and this is reflected in the anxiolytic and sedative effects that reported in laboratory studies.
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| Description | Bromazolam is a benzodiazepine derivative that was first synthesized in the 1970s and has been studied extensively for its psychoactive effects. It has been used in laboratory experiments to study the effects of benzodiazepines on the central nervous system (CNS). Bromazolam is considered to be a “designer drug” due to its structural similarity to other benzodiazepines, such as diazepam and alprazolam. Bromazolam has been used for research purposes in laboratories for more than four decades, but it has not been approved for medical use. Buy Bromazolam Cas 71368-80-4 |
| Synthesis Method | Bromazolam is synthesized by a process known as “Bromination”. This process involves the reaction of a benzodiazepine core with bromine in an organic solvent, such as dimethylformamide (DMF). The bromine reacts with the benzodiazepine core to form a brominated product, which is then purified and isolated. |
| Synthesis Method Details | Design of the Synthesis Pathway The synthesis pathway for Bromazolam involves the condensation of 2-amino-5-bromo-1,3-thiazole with 2-bromo-2′-chloroacetophenone followed by reduction of the resulting imine with sodium borohydride. Buy Bromazolam Cas 71368-80-4Starting Materials 2-amino-5-bromo-1,3-thiazole, 2-bromo-2′-chloroacetophenone, sodium borohydride, methanol, hydrochloric acid, sodium hydroxide, waterReaction Step 1: Dissolve 2-amino-5-bromo-1,3-thiazole (1.0 g, 4.8 mmol) and 2-bromo-2′-chloroacetophenone (1.3 g, 4.8 mmol) in methanol (20 mL) and add hydrochloric acid (1 M) dropwise until the pH reaches 3. Step 2: Stir the reaction mixture at room temperature for 24 hours. Step 3: Add sodium hydroxide (1 M) dropwise until the pH reaches 10. Step 4: Extract the product with ethyl acetate (3 x 20 mL) and dry the organic layer over anhydrous sodium sulfate. Buy Bromazolam Cas 71368-80-4 Step 5: Concentrate the organic layer under reduced pressure to obtain a yellow solid. Step 6: Dissolve the yellow solid in methanol (10 mL) and add sodium borohydride (0.5 g, 13.2 mmol) slowly. Step 7: Stir the reaction mixture at room temperature for 24 hours. Step 8: Quench the reaction with water (10 mL) and extract the product with ethyl acetate (3 x 20 mL). Step 9: Dry the organic layer over anhydrous sodium sulfate and concentrate under reduced pressure to obtain a white solid. Step 10: Recrystallize the white solid from methanol to obtain pure Bromazolam. |
| Scientific Research Application | Bromazolam has been used extensively in laboratory experiments to study the effects of benzodiazepines on the Bromazolam. It has been used to study the effects of benzodiazepines on memory, learning, and behavior. Bromazolam has also been used to study the effects of benzodiazepines on anxiety and depression, as well as their potential therapeutic use in treating these conditions. In addition, bromazolam has been used to study the effects of benzodiazepines on the cardiovascular system, as well as their potential use in treating cardiovascular diseases. Buy Bromazolam Cas 71368-80-4 |
| Mechanism of Action | The mechanism of action of bromazolam is similar to that of other benzodiazepines. It binds to the gamma-aminobutyric acid (GABA) receptor, which is a neurotransmitter receptor found in the brain. When bromazolam binds to the GABA receptor, it results in an increased affinity for GABA, which leads to an increase in GABAergic inhibition of nerve cells in the brain. This inhibition of nerve cells results in a sedative effect. |
| Biochemical and Physiological Effects | The biochemical and physiological effects of bromazolam have been studied extensively in laboratory experiments. The most common effects of bromazolam are sedation, muscle relaxation, and anxiolysis. Bromazolam has also been found to have anticonvulsant effects, as well as an anti-inflammatory effect. In addition, bromazolam has been found to have a protective effect against oxidative stress. Buy Bromazolam Cas 71368-80-4 |
| Advantages and Limitations for Lab Experiments | The advantages of using bromazolam in laboratory experiments include its relatively low cost, the availability of its precursors, and its relatively low toxicity. The main limitation of using bromazolam in laboratory experiments is its relatively low potency compared to other benzodiazepines, such as diazepam and alprazolam. Buy Bromazolam Cas 71368-80-4 |
| Future Directions | Future directions for research on bromazolam include further studies on its effects on the Bromazolam and its potential therapeutic use in treating anxiety and depression. In addition, further research is needed on the effects of bromazolam on the cardiovascular system and its potential use in treating cardiovascular diseases. Finally, further research is needed on the effects of bromazolam on memory, learning, and behavior, as well as its potential therapeutic use in treating these conditions. Buy Bromazolam Cas 71368-80-4 |
| CAS RN | 71368-80-4 |
| Product Name | Bromazolam |
| Molecular Formula | C17H13BrN4 |
| Molecular Weight | 353.2 g/mol |
| IUPAC Name | 8-bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine |
| InChI | InChI=1S/C17H13BrN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3 |
| InChI Key | KCEIOBKDDQAYCM-UHFFFAOYSA-N |
| SMILES | CC1=NN=C2N1C3=C(C=C(C=C3)Br)C(=NC2)C4=CC=CC=C4 |
| Canonical SMILES | CC1=NN=C2N1C3=C(C=C(C=C3)Br)C(=NC2)C4=CC=CC=C4 |
| Origin of Product | China |
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