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Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia and procedural sedation, and to treat severe agitation. It induces sleepiness, decreases anxiety, and causes anterograde amnesia.

The drug does not cause an individual to become unconscious, merely to be sedated^] It is also useful for the treatment of prolonged (lasting over five minutes) seizures. Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek. When given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working. Buy Midazolam hcl online

Side effects can include a decrease in efforts to breathe, low blood pressure, and sleepiness. Tolerance to its effects and withdrawal syndrome may occur following long-term use. Paradoxical effects, such as increased activity, can occur especially in children and older people. There is evidence of risk when used during pregnancy but no evidence of harm with a single dose during breastfeeding. Buy Midazolam hcl online

Midazolam was patented in 1974 and came into medical use in 1982. It is on the World Health Organization’s List of Essential Medicines. Midazolam is available as a generic medication. In many countries, it is a controlled substance. Buy Midazolam hcl online

Procedural sedation

Intravenous midazolam is indicated for procedural sedation (often in combination with an opioid, such as fentanyl), preoperative sedation, for the induction of general anesthesia, and for sedation of people who are ventilated in critical care units. Midazolam is superior to diazepam in impairing memory of endoscopy procedures, but propofol has a quicker recovery time and a better memory-impairing effect. It is the most popular benzodiazepine in the intensive care unit (ICU) because of its short elimination half-life, combined with its water solubility and its suitability for continuous infusion. However, for long-term sedation, lorazepam is preferred due to its long duration of action, and propofol has advantages over midazolam when used in the ICU for sedation, such as shorter weaning time and earlier tracheal extubation. Buy Midazolam hcl online

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Description: Benzodiazepine agonist

Alternative Names: Dormicum,Ro 21-3981/001

Chemical Name: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine hydrochloride

Purity: ≥99%

View All Products for GABA-A Receptor Benzodiazepines

Product Details

Reviews (1)

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Midazolam hydrochloride is a sedative/hypnotic agent that acts at the GABA_A receptor benzodiazepine modulatory site.

Technical Data

M.Wt:

362.23

Formula:

C₁₈H₁₃ClFN₃.HCl

Solubility:

Soluble to 25 mM in water

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

59467-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia.
Kanto
Pharmacotherapy, 1985;5:138

Midazolam and other benzodiazepines.
Olkkola and Ahonen
Handb.Exp.Pharmacol., 2008;182:335

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