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1-Phenyl-2-nitropropene, or simply phenyl-2-nitropropene, or P2NP, as it is commonly referred to, is a chemical compound from the aromatic group of compounds, with the formula C9H9NO2. It is a light-yellow crystalline solid with a distinct smell.[6] Phenyl-2-nitropropene is used in the pharmaceutical industry to manufacture the drug Adderall, an amphetamine mixture used to treat ADHD and narcolepsy. P2NP and other similar nitrostyrenes are also employed in the clandestine manufacture of drugs of the amphetamine class, and are listed as drug precursors in many countries. Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

P2NP 1-Phenyl-2-nitropropene CAS 705-60-2 Product Information

Product Name:1-Phenyl-2-nitropropene
Synonyms:1-(PHENYL) 2-NITROPROPENE;2-NITROPROP-1-ENYLBENZENE;2-NITRO-1-PHENYLPROPENE;BETA-METHYLNITROSTYRENE;BETA-METHYL-BETA-NITROSTYRENE;TIMTEC-BB SBB003925;TRANS-BETA-METHYL-BETA-NITROSTYRENE;trans-β-methyl-β-nitrostyrene
CAS NO:705-60-2
Molecular Weight:163.17
Molecular Formula:C9H9NO2
Boiling Point:263.0±9.0 °C(Predicted)
Melting point:63-65 °C (lit.)
Density:1.141±0.06 g/cm3(Predicted)
Appearance:Yellow Crystalline Powder
Purity:>98%
Solubility:Acetone, Chloroform, Dichloromethane, Methanol
Storage:2-8°C
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P2NP 1-phenyl-2-nitropropene uses

1-Phenyl-2-propanone (P-2-P), also known as benzyl methyl ketone (BMK), is the main precursor used in amphetamine synthesis.It is used in the production of pharmaceuticals, for instance, for drug Adderall, a drug used to treat ADHD and narcolepsy.1-phenyl-2-nitropropene is used in the pharmaceutical industry to manufacture the drug Adderall, an amphetamine mixture used to treat ADHD and narcolepsy. It is also used in the clandestine manufacture of drugs of the amphetamine class. Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

P2NP 1-phenyl-2-nitropropene synthesis

In the lab, phenyl-2-nitropropene is produced by the reaction of benzaldehyde and nitroethane in the presence of a basic catalyst like n-butylamine. The reaction is a nitroaldol reaction, and is a variant of a Knoevenagel condensation reaction, which is one of a broader class of reactions called Henry condensations, or simply Henry reactions. These are named after the German chemist Emil Knoevenagel, and the Belgian chemist Louis Henry, respectively.

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Uses

In the pharmaceutical industry, P2NP is used to produce a racemic amphetamine mixture, branded under the trade names Adderall and Mydayis, amongst others. In this case, the double bond is hydrogenated and the nitro group is reduced,[10] thus 1-phenyl-2-nitropropene becomes 1-phenyl-2-aminopropane, which is another name for amphetamine. Different reducing agents commonly lithium aluminium hydride (LAH), sodium borohydride,aluminum amalgam or Raney nickel are used in suitable solvents like isopropyl alcohol or tetrahydrofuran. Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Reduction of P2NP to Amphetamine

The above diagram depicts P2NP reduction to amphetamine by either LAHsodium amalgamRaney nickel, or palladium used as catalystsPlatinum, in the form of Adams’ catalyst, can also be used.[7]

P2NP can also be reduced to phenylacetone (P2P), the precursor in the synthesis of methamphetamine by a few methods. One in which phenyl-2-nitropropene is reduced to phenyl-2-nitropropane using sodium borohydride, followed by hydrolysis of the nitro group with hydrogen peroxide and potassium carbonate to produce phenylacetone (1-phenyl-2-propan-2-one).[11] In another method, iron is the reducing agent and hydrochloric acid or acetic acid are used as catalysts forming an intermediate which hydrolyzes into phenylacetone as well.[11]

Synthesis

In the lab, phenyl-2-nitropropene is produced by the reaction of benzaldehyde and nitroethane in the presence of a basic catalyst like n-butylamine. The reaction is a nitroaldol reaction, and is a variant of a Knoevenagel condensation reaction, which is one of a broader class of reactions called Henry condensations, or simply Henry reactions. These are named after the German chemist Emil Knoevenagel, and the Belgian chemist Louis Henry, respectively. Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Synthesis of phenyl-2-nitropropene

In this type of reaction, the basic catalyst deprotonates the nitroethane to form a resonance stabilized anion. This anion nucleophilically adds to the aldehyde forming a β-nitro alcohol, which is subsequently dehydrated to yield the nitroalkene. Water is produced as a byproduct, and must be actively removed from the reaction mixture. Often, primary amines like n-butylaminemethylamine, and ethylamine are used as catalysts, as is anhydrous ammonium acetate at times.[6]

Many other drugs of the amphetamine class are produced in a similar fashion, where substituted benzaldehyde derivatives are used to produce a different nitrostyrene, which is later reduced to the desired amine. One such reaction is the Knoevenagel condensation of piperonal with nitroethane, yielding 3,4-methylenedioxy-1-phenyl-2-nitropropene, or MDP2NP. This is reduced to 3,4-methylenedioxyamphetamine, or MDA, which can be methylated to 3,4-methylenedioxymethamphetamine, or MDMA.[9] Another uses 2,5-dimethoxybenzaldehyde and nitromethane to yield 2,5-dimethoxy-β-nitrostyrene. Many of these Knoevenagel condensations were used by Dr. Alexander Shulgin to yield over 100 amphetamine derivatives, which he detailed in his book, PiHKAL.Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Safety and Storage

P2NP is labeled as harmful by the GHS, and is a known irritant. Thus, breathing fumes and direct skin and eye contact should be avoided. The median lethal dose for oral exposure in rats and mice is greater than 500 mg/kg and 1176 mg/kg, respectively. Based on available data, the classification criteria are not met to classify P2NP as a carcinogen. However, the toxicological properties have not been thoroughly investigated. Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

P2NP should be stored at 2 °C to 8 °C and away from strong oxidizing agents. At higher temperatures, P2NP is not very stable, and degrades with time.

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Description

1-Phenyl-2-nitropropene, also known as P2NP, is a chemical compound from the aromatic group of compounds with the formula C9H9NO2  . It is a stable compound with both aromatic and alkyl substituents that can act as a Michael acceptor, making it useful in organic synthesis and medicinal chemistry . Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Synthesis Analysis

In the lab, 1-Phenyl-2-nitropropene is produced by the reaction of benzaldehyde and nitroethane in the presence of a basic catalyst like n-butylamine . This reaction is a nitroaldol reaction, a variant of a Knoevenagel condensation reaction . The reaction forms a Schiff base intermediate and water, which is removed via a Dean-Stark trap to drive the reaction to completion, producing the desired nitropropene product . Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Molecular Structure Analysis

1-Phenyl-2-nitropropene is a chemical compound with the formula C9H9NO2 . Structurally, it is a derivative of acrylonitrile, incorporating a phenyl group and a nitro group . The double bond between carbon atoms 2 and 3 is conjugated with the nitro group, resulting in a highly polar and electron-rich system . Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Chemical Reactions Analysis

One of the significant properties of 1-phenyl-2-nitropropene is its ability to act as a Michael acceptor, which means it can react with various nucleophiles such as alcohols, amines, and thiols to form new carbon-nitrogen bonds . Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Physical And Chemical Properties Analysis

1-Phenyl-2-nitropropene is a colorless to yellow liquid with a characteristic odor . It is an alkyl nitro compound with both aromatic and alkyl substituents . It is a stable compound at room temperature and pressure, provided it is protected from oxygen .

Scientific Research Applications

Organic Synthesis

P2NP finds extensive applications in organic synthesis Its reactivity towards reducing agents facilitates the synthesis of amphetamine and methamphetamine derivatives, which are utilized as central nervous system stimulants or pharmaceutical intermediates .

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P2NP is also used in the synthesis of specialty compounds Its versatility and compatibility with a wide range of chemical transformations make it a valuable ingredient in the synthesis of diverse compounds . Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

Drug Development

P2NP plays a pivotal role in drug development Its unique properties allow chemists to explore new synthetic pathways, leading to the discovery of novel drugs .

Materials Science

In the field of materials science, P2NP is used as a precursor in the synthesis of various materials Its unique reactivity and versatility make it a valuable tool in the development of new materials .

Future Directions

1-Phenyl-2-nitropropene has potential applications in pharmaceutical synthesis, herbicidal properties, and antibacterial activities . It plays a significant role in the production of certain medications such as Adderall . It can also be utilized in the formulation of herbicides to control unwanted plant growth and weeds . Its future directions could include further exploration of these applications and continued study of its properties and potential uses . Buy P2NP 1-Phenyl-2-nitropropene 705-60-2

properties

CAS RN705-60-2, 18315-84-9Source    
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Retrosynthesis Analysis

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مسحوق API عالي الجودة P2np 1-Phenyl-2-Nitropropene CAS 705-60-2/59774-06-0/25547-51-7.

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