-
Purchase Bromazolam Powder Online
Purchase Bromazolam Powder Online. What is Bromazolam? Bromazolam was first synthesized back in 1976, but was never commercially marketed and not identified until much later in the early 2000s by the EMCDDA in Sweden.Also known as 8-bromo-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine or XLI-268, Buy Bromazolam online always available.It shares most of its structural properties with Alprazolam (brand…
-
Sell Diazepam powder online
Sell Diazepam powder online. Benzodiazepines are widely used in medicine to treat anxiety and insomnia. These are synthetic substances normally seen as pharmaceutically-manufactured tablets, capsules and occasionally as injectables. They act as depressants of the central nervous system (CNS). Chlordiazepoxide (Librium) was the first to be synthesised in 1957 and introduced into medicine in 1961….
-
Buy N-Desethyl Etonitazene online.
Buy N-Desethyl Etonitazene online. N-Desethylisotonitazene (norisotonitazene) is a benzimidazole opioid with potent analgesic effects which has been sold as a designer drug. It was first identified in 2023 as an active metabolite of the closely related compound isotonitazene, and was found to have similar potency. It is one of the strongest benzimidazole opioids discovered, with an analgesic strength 20 times stronger than fentanyl. Starting in 2023, it has become…
-
Buy etonitazepyne Cas 2785346-75-8
Buy etonitazepyne Cas 2785346-75-8. Etonitazepyne (N-pyrrolidino etonitazene) is a benzimidazole derivative with potent opioid effects which has been sold over the internet as a designer drug and linked to numerous cases of overdose. Product Name: EtonitazepyneCAS No.: 2785346-75-8Molecular Formula: C22H26N4O3Molecular Weight: 394.47EINECS Number: 2785346-75-8Storage Condition: -20°CPurity: ≥98%, high qualityStability: ≥1 yearStandard: Pharmaceutical GradeAppearance: Brown or Red-Brown Powder Etonitazepyne (N-pyrrolidino etonitazene) World Health Organization…
-
Buy Pyrazolam Cas 39243-02-2
Pyrazolam (SH-I-04) is a benzodiazepine derivative originally developed by a team led by Leo Sternbach at Hoffman-La Roche in the 1970s. It has since been “rediscovered” and sold as a designer drug since 2012. Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine. 8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine Product Name:Pyrazolam Synonyms: Pyrazolam 8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine formaty Pyrazolam solution 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-bromo-1-methyl-6-(2-pyridinyl)- 8-Bromo-1-methyl-6-(2-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]be nzodiazepine ANTIOXIDANT PUB-380 Pyrazolam 1 In…
-
Buy Protonitazene Hcl powder
Buy Protonitazene Hcl powder. Territorial Availability: Available through Bertin Technologies only in France Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details. Special Advice: Please check regulation status before ordering; additionel fees can apply. Synonyms: Correlated keywords: Product Overview:Protonitazene (hydrochloride) is…
-
Buy Tetracaine hcl online
Buy Tetracaine hcl online. Tetracaine, also known as amethocaine, is an ester local anesthetic used to numb the eyes, nose, or throat.[2] It may also be applied to the skin before starting an intravenous (injection) to decrease pain from the procedure.[3] Typically it is applied as a liquid to the area.[2] Onset of effects when used in the eyes is within 30 seconds…
Bromazolam Powder Sales
Buy Bromazolam Powder Online
Sell Bromazolam Powder Online
About Us.
Bromazolam Powder Sales is one of the largest Supplier, Agent and Distributors of Bromazolam powder online , Pharmaceutical Intermediates, Dissociatives, Chemical Reagent, Acid & Alkaline, Inorganic Chemical Materials, Food Additives, Stimulants, Plant Extract, Raw Steroid Hormones, API in Hongkong and other locations like mainland China, Vietnam and Taiwan. Bromazolam Powder Sales has been adhering to the business philosophy of providing the best products, the most efficient service and the most reasonable price for the customers since its establishment in 2014. Our company is specialized in supplies of starting materials and intermediaries of steroid hormone by bio-conversion, API and intermediate chemical synthesis. More to that, our manufacturers have three R&D centers, which are located at Fermentation Factory, Chemical Synthesis Factory. New product development, process research and process optimization can be carried out at the same time. And it realizes the development, laboratory scale production and pilot production from grams, kilograms to tons. Based on the principle of ecology priority and green development, our company has continuously invested in environmental protection, developed and applied green production process, insistently strengthened pollution management and constantly consolidated the foundation for the operation and development over the years. The future will be better and better, we will continue to make our due contribution to human health by science and sincerity uses.
We Ship from Hongkong, Taiwan & Vietnam Safely. No shipping from Mainland China for Now!!!
What is Bromazolam ?
Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) which was first synthesised in 1976, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016. It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines. Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81 nM at the α1 subtype, 0.69 nM at α2 and 0.62 nM at α5.The “common” dosage range for users of bromazolam was reported to be 1–2 mg, suggesting its potency is similar to alprazolam.
Adverse effects
Because bromazolam is relatively new, epidemiologically research regarding the individual’s health effects as well as the effects on the public health are quite scarce. Most of the knowledge about the effects are known from case studies and individual reports.
The typical effects of benzodiazepines used in medical science are muscle relaxation, amnesia, sedation, anxiolysis and anticonvulsive activity (used to treat epilepsy). Therefore are benzodiazepines frequently used to treat illnesses such as anxiety, insomnia, muscle spasms or epilepsy.
According to studies even short use of bromazolam could lead to tolerance and psychological, as well as physical dependence. Benzodiazepine-like compounds are rarely fatal when taken alone but can cause central nervous system depression when combined with other medication or drugs.
Common adverse effects of benzodiazepines are somnolence, impaired balance, ataxia, loss of coordination, impaired thinking and self-assessment capability, muscle weakness, confusion, slurred speech, blurred vision, amnesia, dizziness, drowsiness, lethargy, fatigue and palpitations. At high doses, they could induce delirium, auditory and visual hallucinations, seizures, deep sleep and coma.
To study the potential addictive nature of bromazolam a two-lever drug discrimination test was performed. Rats trained to discriminate against the benzodiazepine midazolam were used to evaluate the abuse potential of bromazolam. They found that bromazolam resulted in full dose-dependent substitution with an ED50 of 0.54 mg/kg. In comparison the ED50 of midazolam and diazepam were 0.09 and 0.66 respectively.
Pharmacology
Pharmacokinetics
Metabolism
Not many studies have been conducted on the biotransformation of bromazolam, mainly because this drug is relatively new. However, in a study of Wagmann et al. (2020), the biotransformation of bromazolam is studied in depth. The results of this study are described in the text below.
Blood plasma and urine of two individuals suspected of taking bromazolam were analysed for bromazolam and its metabolites. Bromazolam was detected in all four of the samples. One of the urine samples contained 8 bromazolam metabolites these were: phenyl-hydroxy bromazolam, 4-hydroxy bromazolam, α-hydroxy bromazolam, α-4-dihydroxy bromazolam, bromazolam N-glucuronide, phenyl-hydroxy bromazolam glucuronide, α-hydroxy bromazolam glucuronide, and 4-hydroxy bromazolam glucuronide. In the blood plasma sample of the same individual only the three mono-hydroxylated metabolites were found.
The urine of the other individual only contained two metabolites, which were also found in the other urine sample, and the blood plasma did not show any metabolite of bromazolam present in the body.
A study where pooled human liver S9 fractions (pHLS9) were incubated with bromazolam was conducted. Seven, out of the eight urine, bromazolam metabolites were found in the pHLS9 samples. Phenyl-hydroxylated glucuronide bromazolam was not found in the pHLS9 samples.
Several monooxygenases and glucuronosyltransferases have been screened, in vitro, for activity of the biotransformation of bromazolam. Out of the eight metabolites found in a urine sample seven metabolites have been linked to monooxygenases and glucuronosyltransferases activity.
Phase I
Phenyl-hydroxy bromazolam, 4-hydroxy bromazolam, α-hydroxy bromazolam, and α-4-dihydroxy bromazolam. The formation of phenyl-hydroxy bromazolam was catalysed by CYP2B6, CYP2C19, and CYP3A4. 4-hydroxy bromazolam, as well as α-hydroxy bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally, CYP2C9 was found to catalyse the formation of α-hydroxy bromazolam as well. α-4-dihydroxy bromazolam was only found in incubations with CYP3A4.
Phase II
Bromazolam N-glucuronide, phenyl-hydroxy bromazolam glucuronide, α-hydroxy bromazolam glucuronide, and 4-hydroxy bromazolam glucuronide, were detected as phase II metabolites.
Bromazolam N-glucuronidation was found to be catalysed by UGT1A4 and UGT2B10. The formation of α-hydroxy bromazolam glucuronide was catalysed by UGT2B4. And 4-hydroxy bromazolam glucuronidation was catalysed by UGT1A3, UGT1A6, UGT1A9, UGT2B7 and UGT2B15.
The enzyme responsible for the catalysis for the phenyl-hydroxy bromazolam glucuronidation formation was not identified.
Pharmacodynamics
Benzodiazepine like compounds are acting as positive allosteric modulators to the gamma-aminobutyric acid GABAA receptor. GABA is the main inhibitor of neurotransmitters in the brain and modulates the activity of many neurons.
Benzodiazepines bind to the GABAA receptor inducing a conformational change leading to an increased affinity to GABA.
The allosteric binding site is situated in a “pocket” created by the alpha and gamma subunits. The pharmacological effects on benzodiazepines vary based on which alpha subunit of the GABAA receptor the benzodiazepine binds to.
The sedative, anterograde amnesic, anticonvulsant actions, and the addictive nature of benzodiazepines, are due to the binding to the α1 subunit of the (GABA)A receptor. Binding to the α2 subunit will cause the anxiolytic effects, and binding to the α2, α3, and α5 subunits will lead to the myorelaxant effects.
According to research done by the WHO bromazolam binds to the α1, α2, and α5 subunits.
Chemistry
Synthesis
The synthetic pathway of the synthesis is executed as follows: In the initial step, 2-Amino-5-bromobenzophenone undergoes acylation, leveraging its amino group with a lone pair on the nitrogen atom. This lone pair facilitates a nucleophilic attack, where the nitrogen attacks the carbon of chloroacetyl chloride, inducing a negatively charged oxygen. Subsequently, the oxygen re-establishes the carbon-oxygen double bond, expelling a chloride ion, leading to the formation of bromoacetamide-2-chloro-5-benzophenone.
Following this, bromoacetamide-2-chloro-5-benzophenone engages in a nucleophilic substitution reaction with ammonium hydroxide as a nucleophile, replacing the second chloride ion with ammonia. This reaction yields 2-amino-N-(2-benzoyl-4-bromophenyl)acetamide.
Upon the formation of 2-amino-N-(2-benzoyl-4-bromophenyl)acetamide, an intramolecular reaction ensues, resulting in 7-bromo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one, characterized by a seven-membered ring known as diazepine.
Subsequently, through the aid of acetohydrazide, another acylation event takes place, giving rise to a 1,2,4-triazole ring and ultimately yielding the synthesis of Bromazolam.[14][17][18][19] The synthesis of Bromazolam is shown below.
Society and culture
Legal status
In the United States, bromazolam is unscheduled at the federal level. However a number of states such as Virginia have placed bromazolam into Schedule 1 at the state level, but this does not include the chloro analog phenazolam.
Despite being unscheduled there have been several arrests in the United States for mismarketing bromazolam as alprazolam, typically in the shape of brand name Xanax tablets which constitutes a counterfeit drug charge among others.
In Illinois, at least 1 person has been arrested for “unlawful possession of a controlled substance, a Class 4 felony.” for the possession of less than 15 grams (½ oz.) of bromazolam, similar to being charged for unlawful possession of alprazolam in Illinois. It’s unknown if this arrest involved counterfeit Xanax shaped tablets or powder. However bromazolam is not scheduled in Illinois.
In June 2022, the U.S. Department of Justice reported that bromazolam seizures were “surging” across the United States, driven in part by increasing detections alongside fentanyl. Illicit opioids such as heroin or fentanyl analogues are mixed with bromazolam and sold at the street level; the product is sometimes referred to as “benzo-dope.”The Indiana Department of Health reported that bromazolam represented 73% of all novel or designer benzodiazepines detected in the first six months of 2023. Of 1,051 blood toxicology samples containing bromazolam reported between January and June 2023, 83% were fentanyl positive, suggesting that bromazolam is commonly mixed with fentanyl.
In the United Kingdom, Bromazolam is a Class C controlled substance.